A data model for managing drug therapy within a patient data management system for intensive care units

The major intent of this article was to describe the design principles of the drug-therapy documentation module of the Patient Data Management System (PDMS) ICUData, in routine use at the intensive care unit (ICU) of the Department of Anesthesiology and Intensive Care Medicine at the University Hospital of Giessen, Germany, since February 1999. The new drug management system has been in routine use since March 2000. Until 8 January 2001, 1140 patients have been documented using this approach. It could be demonstrated that it was possible to transform the formerly unstructured text-based documentation into a detailed and structured model. The mediated benefit resulted in the automatic calculation of fluid balance. Further, detailed statistical analyses of therapeutic behavior in drug administration are now possible.     

FA and tocopherol composition of Vietnamese oilseeds

Seeds of 40 oilseed species from 23 different plant families (Brassicaceae, Cucurbitaceae, Fabaceae, Sapindaceae, Malvaceae, Gnetaceae, Clusiaceae, Bruseraceae, Ranunculaceae, Convolvulaceae, Amaranthaceae, Tiliaceae, Basellaceae, Solanaceae, Umbelliferae, Labiatae, Compositae, Theaceae, Euphorbiaceae, Caesalpiniaceae, Sapotaceae, Anacardiaceae, and Connaraceae) grown in Vietnam were analyzed for oilseed oil content, FA, and vitamin E. The seed oil content varied between 0.2 g/100 g for Mangifera indica and 75.7 g/100 g for Calophyllum inophyllum, whereas only nine seeds contained more than 40% oil. The tocopherol content ranged from 26 (Sapindus mukorossi) to 9361 mg/kg (Litchi chinensis). In nine seed oils unusual FA such as conjugated, cyclopropenoic, or epoxy FA were found.     

Compact spot-size converters with fiber-matched antiresonant reflecting optical waveguides

We propose a concept for InGaAsP-InP 1.55-microm lasers integrated with spot-size converters based on modal interference between the modes of the structure formed by an active waveguide and an underlying fiber-matched antiresonant reflecting optical waveguide. Simulation results show that the spot-size converters exhibit low transformation loss, and narrowed far-field emission patterns (10 degrees x 20 degrees) and reduce the coupling loss to standard single-mode fibers from 8 to 2.6 dB over lengths approximately 200 microm shorter than the adiabatic concept. A tolerant design to fabrication variations is also proposed, which could be realized by standard processing techniques.     

The Hydrogeochemistry of Arsenic in the Clara Mine,Germany

Abstract.   The oxidative dissolution of primary arsenic-bearing sulfide minerals in barite-fluorite veins is a potential source of arsenic in the Clara Mine. Geological structures, especially the mineral veins, provide potential pathways for the water. The highest arsenic concentrations are found in ground water within the eastern part of the mine. Arsenic and major ions are positively correlated and provide evidence that arsenic is likely derived locally from the water-vein/water-rock interaction. Geochemical modeling with PHREEQC shows all the arsenate mineral phases to be significantly undersaturated, although secondary arsenate minerals are common in the oxidized part of the deposit. The mine waters plot near the boundary of Fe(OH)₃ and Fe²⁺ in the pH-Eh diagram for the As-Fe-S-H₂O-system. Arsenic occurs as the 5-valent species and . Statistical analysis illustrates a strong association between As, Fe, pH, and HCO₃. Oxidation of the primary As-bearing minerals, such as pyrite and arsenopyrite, and the subsequent behavior of the oxyanion, arsenate, generally controls the distribution and speciation of arsenic. The low concentrations of dissolved As is due to co-precipitation and adsorption of arsenate by Fe, Al, and Mn (oxy)hydroxides.     

Coded excitation with spectrum inversion (CEXSI) for ultrasound array imaging

In this paper, a scheme called coded excitation with spectrum inversion (CEXSI) is presented. An established optimal binary code whose spectrum has no s and possesses the least variation is encoded as a burst for transmission. Using this optimal code, the decoding filter can be derived directly from its inverse spectrum. Various transmission techniques can be used to improve energy coupling within the system pass-band. We demonstrate its potential to achieve excellent decoding with very low (<80 dB) side-lobes. For a 2.6 /spl mu/s code, an array element with a center frequency of 10 MHz and fractional bandwidth of 38%, range side-lobes of about 40 dB have been achieved experimentally with little compromise in range resolution. The signal-to-noise ratio (SNR) improvement also has been characterized at about 14 dB. Along with simulations and experimental data, we present a formulation of the scheme, according to which CEXSI can be extended to improve SNR in sparse array imaging in general.     

Phase reconstruction from intensity measurements in linear systems

The phase of a signal at a plane is reconstructed from the intensity profiles at two close parallel screens connected by a small abcd canonical transform; this applies to propagation along harmonic and repulsive fibers and in free media. We analyze the relationship between the local spatial frequency (the signal phase derivative) and the derivative of the squared modulus of the signal under a one-parameter canonical transform with respect to the parameter. We thus generalize to all linear systems the results that have been obtained separately for Fresnel and fractional Fourier transforms.     

Synthesis of Si3N4 using sepiolite and various sources of carbon

Sepiolite of Turkish origin was used as Si precursor in the syntheses of silicon nitride (Si₃N₄) powders by carbothermal reduction-nitridation (CRN) by mixing with several reducing agents i.e. charcoal, carbon black and petroleum coke as discrete particles and acrylonitrile as an intercalation medium. Purified sepiolite samples with a pre-determined C/SiO₂ ratio of 4 yielded Si₃N₄ powders after firing at temperatures 1300–1475°C under continuous nitrogen flow. The various sepiolite-reducing agent combinations were evaluated. The / ratio and secondary phase content of the powders after CRN were found to depend on temperature, time, heating rate and on the physicochemical properties of the precursor used such as, surface area and mixing of the reactants.     

Sepiolite-PAN intercalation used as Si3N4 forming precursor

Silicon nitride (Si₃N₄) formation was investigated using sepiolite and polyacrylonitrile as silicon and carbon source, respectively. It was found that purified sepiolite could readily adsorb a sufficient amount of acrylonitrile (AN) reagent without pre-treatment. Polymerisation of sepiolite-AN mixtures and subsequent cyclization of the polymerised complex yielded a precursor, which was found ideal as a starting material in carbothermal reduction-nitridation (CRN) for the formation of silicon nitride powders. The quantity of silicon nitride, grain size and morphology were found to be dependent on the reaction conditions and starting reagent. Fine grain size, high surface area (up to approx. 12.4 m²/g) powders of mainly -Si₃N₄ were obtained via pyrolysis of sepiolite-PAN complex after 4 h heating at 1400°C in 1000 ml/min nitrogen flow with a heating rate of 300°C/h. Mg retained in the molecular structure of the mineral must have promoted the formation of -grains in CRN process.     

Infrastructures for the environment of multiagent systems

The notion of environment is receiving an increasing attention in the development of multiagent applications. This is witnessed by the emergence of a number of infrastructures providing agent designers with useful means to develop the agent environment, and thus to structure an effective multiagent application. In this paper we analyse the role and features of such infrastructures, and survey some relevant examples. We endorse a general viewpoint where the environment of a multiagent system is seen as a set of basic bricks we call environment abstractions, which (i) provide agents with services useful for achieving individual and social goals, and (ii) are supported by some underlying software infrastructure managing their creation and exploitation. Accordingly, we focus the survey on the opportunities that environment infrastructures provide to system designers when developing multiagent applications.     

Design of phononic materials/structures for surface wave devices using topology optimization

We develop a topology optimization approach to design two- and three-dimensional phononic (elastic) materials, focusing primarily on surface wave filters and waveguides. These utilize propagation modes that transmit elastic waves where the energy is contained near a free surface of a material. The design of surface wave devices is particularly attractive given recent advances in nano- and micromanufacturing processes, such as thin-film deposition, etching, and lithography, which make it possible to precisely place thin film materials on a substrate with submicron feature resolution. We apply our topology optimization approach to a series of three problems where the layout of two materials (silicon and aluminum) is sought to achieve a prescribed objective: (1) a grating to filter bulk waves of a prescribed frequency in two and three dimensions, (2) a surface wave device that uses a patterned thin film to filter waves of a single or range of frequencies, and (3) a fully three-dimensional structure to guide a wave generated by a harmonic input on a free surface to a specified output port on the surface. From the first to the third example, the resulting topologies increase in sophistication. The results demonstrate the power and promise of our computational framework to design sophisticated surface wave devices.